Identifying Energy Barriers in RNA Folding Through Kinetic Model Enumeration
نویسندگان
چکیده
منابع مشابه
Exhaustive Enumeration of Kinetic Model Topologies for the Analysis of Time-Resolved RNA Folding
Unlike protein folding, the process by which a large RNA molecule adopts a functionally active conformation remains poorly understood. Chemical mapping techniques, such as Hydroxyl Radical (·OH) footprinting report on local structural changes in an RNA as it folds with single nucleotide resolution. The analysis and interpretation of this kinetic data requires the identification and subsequent o...
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Early attempts include Pipas & McMahon (1975), who simply summed over all possible secondary structures and evaluated them with respect to free-energy functions. Biological and thermodynamical principles were then used to advanced free-energy functions to get more accurate predictions, which have been used to great effect in algorithms such as UNAFold (Markham et al. 2008) and RNAfold (Hofacker...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.943